ABSTRACT
OBJECTIVE: To identify the different variables that can cause liver injury in a patient hospitalized for COVID-19. MATERIALS AND METHODS: A prospective cohort study that included patients with COVID-19 who were admitted to the Central University Hospital of the State of Chihuahua from April 2020 to November 2020. A univariate analysis was performed to find the frequencies of demographic characteristics and of the drugs prescribed, as well as a comparison of means of the biochemical parameters using Student's t test. RESULT(S): One hundred thirty-four patients with a confirmed diagnosis of COVID-19 were included, who underwent liver function parameters and averages were obtained on the day of admission, on the fifth day and the last values recorded for improvement or death. Of the parameters, albumin levels showed a significant decrease on the 5th and last day of hospitalization compared to the first day of admission. On the other hand, the levels of alkaline phosphatase, gamma-glutamyl transferase and erythrocyte sedimentation rate increased significantly on the 5th and last day of stay. CONCLUSION(S): There are different mechanisms that can generate liver injury associated with COVID-19. Of these, the uncontrolled inflammatory response that occurs can alter liver function tests. Our results found a relationship between the alteration of different laboratory parameters and the days of hospital stay of patients with the disease.Copyright © 2023 Comunicaciones Cientificas Mexicanas S.A. de C.V.. All rights reserved.
ABSTRACT
Background: Since the beginning of the pandemic caused by the SARS-CoV-2 virus, risk factors have been identified. These can lead to complications in patients with comorbidities, acute renal injury is one of the most important complications of COVID-19. Objective: To identify a possible relationship between the indicators of the patient's renal status upon admission and the outcome. Materials and Methods: An observational study (retrospective cohort) of patients (series of confirmed cases of COVID-19) who were admitted to the Hospital Central del Estado de Chihuahua, Mexico, from April 1stto October 20th, 2020. A binary logistic regression model was performed. Results: There were included 266 patients. It was found that 82% did not present acute kidney injury on admission, 11.7% were in stage AKIN I, 13.5% AKIN II and 4.5% AKIN III. Patients with COVID-19 without acute renal injury had a higher probability of hospital discharge than those who developed acute renal injury. Conclusions: Kidney injury influences the prognosis of patients with COVID-19;patients out of range of acute kidney injury based on basal serum creatinine have more probability of being discharged by clinical improvement.